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Description
NTB-A/SLAMF6 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms NTB A, SLAMF6, Ly108, NK T B antigen, CD352, KALI Accession Q96DU3 1 Amino Acid Sequence Gln22 Met226, with C terminal Fc Expression System HEK293 Molecular Weight 60 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | NTB-A, SLAMF6, Ly108, NK-T-B-antigen, CD352, KALI |
| Accession | Q96DU3-1 |
| Amino Acid Sequence | Gln22-Met226, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Veillette, A. (2006) Immunol. Rev. 214:22. Bottino, C. et al. (2001) J. Exp. Med. 194:235. Fraser, C.C. et al. (2002) Immunogenetics 53:843. Eissmann, P. and C. Watzl (2006) J. Immunol. 177:3170. |
Background
NTB-A (NK-T-B-antigen), also known as Ly108 and SLAMF6, is a 60 kDa type I transmembrane glycoprotein that belongs to the SLAM subgroup of the CD2 family. Mature human NTB-A contains a 205 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain. It also contains a 21 aa transmembrane segment and an 84 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs (ITSMs). An alternately spliced isoform is truncated in the cytoplasmic domain and lacks the two ITSMs. NTB-A functions as an activating coreceptor on NK and T cells. Tyrosine phosphorylation in the membrane proximal ITSM enables specific association with EAT-2, an interaction that is required for NTB-A mediated cytotoxicity of NK cells.
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